Soyasaponins A1 and A2 exert anti-atherosclerotic functionalities by decreasing hypercholesterolemia and inflammation in high fat diet (HFD)-fed ApoE-/- mice.
Identifieur interne : 000048 ( Main/Exploration ); précédent : 000047; suivant : 000049Soyasaponins A1 and A2 exert anti-atherosclerotic functionalities by decreasing hypercholesterolemia and inflammation in high fat diet (HFD)-fed ApoE-/- mice.
Auteurs : Qunying Xie [République populaire de Chine] ; Fei Xiong ; Xinglong Wu ; Junbin Chen ; Xiangfu Gu ; Chuhong Su ; Lingyu Xiao ; Zhongdaixi Zheng ; Yuanhao Wei ; Hidayat Ullah ; Longying ZhaSource :
- Food & function [ 2042-650X ] ; 2020.
Descripteurs français
- KwdFr :
- Alimentation riche en graisse (MeSH), Animaux (MeSH), Aorte (MeSH), Athérosclérose (traitement médicamenteux), Composés phytochimiques (usage thérapeutique), Facteur de transcription RelA (métabolisme), Hypercholestérolémie (traitement médicamenteux), Inflammation (traitement médicamenteux), Inhibiteur alpha de NF-KappaB (métabolisme), Lipides (sang), Mâle (MeSH), Plaque d'athérosclérose (sang), Récepteur de type Toll-4 (métabolisme), Saponines (pharmacologie), Soja (composition chimique), Souris (MeSH), Souris invalidées pour les gènes ApoE (MeSH), Transduction du signal (MeSH).
- MESH :
- composition chimique : Soja.
- métabolisme : Facteur de transcription RelA, Inhibiteur alpha de NF-KappaB, Récepteur de type Toll-4.
- pharmacologie : Saponines.
- sang : Lipides, Plaque d'athérosclérose.
- traitement médicamenteux : Athérosclérose, Hypercholestérolémie, Inflammation.
- usage thérapeutique : Composés phytochimiques.
- Alimentation riche en graisse, Animaux, Aorte, Mâle, Souris, Souris invalidées pour les gènes ApoE, Transduction du signal.
English descriptors
- KwdEn :
- Animals (MeSH), Aorta (MeSH), Atherosclerosis (drug therapy), Diet, High-Fat (MeSH), Hypercholesterolemia (drug therapy), Inflammation (drug therapy), Lipids (blood), Male (MeSH), Mice (MeSH), Mice, Knockout, ApoE (MeSH), NF-KappaB Inhibitor alpha (metabolism), Phytochemicals (therapeutic use), Plaque, Atherosclerotic (blood), Saponins (pharmacology), Signal Transduction (MeSH), Soybeans (chemistry), Toll-Like Receptor 4 (metabolism), Transcription Factor RelA (metabolism).
- MESH :
- chemical , blood : Lipids.
- blood : Plaque, Atherosclerotic.
- chemistry : Soybeans.
- drug therapy : Atherosclerosis, Hypercholesterolemia, Inflammation.
- chemical , metabolism : NF-KappaB Inhibitor alpha, Toll-Like Receptor 4, Transcription Factor RelA.
- chemical , pharmacology : Saponins.
- chemical , therapeutic use : Phytochemicals.
- Animals, Aorta, Diet, High-Fat, Male, Mice, Mice, Knockout, ApoE, Signal Transduction.
Abstract
Atherosclerosis is a chronic inflammatory disease causing coronary heart attacks and strokes. Soyasaponins (SS), the phytochemicals naturally existing in soybeans and their products, have been shown to reduce hypercholesterolemia and inflammation, which are intimately related to the genesis and development of atherosclerosis. However, the anti-atherosclerotic functionality of soyasaponins remains unknown. The aim of this study was to investigate the effects of the supplementation of two types of soyasaponin monomers (A1 and A2) on atherosclerotic plaque formation, serum lipid profiles, and inflammation in ApoE gene knockout (ApoE-/-) mice. Sixty 5-week-old ApoE-/- male mice were fed with a high-fat diet (HFD) and intervened by SSA1 and SSA2 (10 and 20 μmol per kg BW, respectively) or simvastatin (10 μmol per kg BW) for 24 weeks. The atherosclerotic lesions in the aorta, aortic root, and innominate artery, lipid profile and inflammatory markers in serum, and TLR4/MyD88/NF-κB signaling in arterial tissues were determined. SSA1 and SSA2 decreased the plaque ratio in the aortic root and innominate artery but not in the entire aorta. In serum, SSA1 reduced TG, TC, and LDL-C but increased HDL-C; SSA2 decreased TC, TG, and LDL-C but did not affect HDL-C. Meanwhile, SSA1 increased TG, SSA2 increased TC, and both of them increased bile acids in the feces. SSA1 and SSA2 lowered TNF-α, MCP-1, and hs-crp in serum. Furthermore, SSA1 and SSA2 reduced the TLR4 and MyD88 expressions in the aorta and innominate artery and inhibited NF-κB p65 and IκBα phosphorylation in the aorta. These results suggest that SSA1 and SSA2 exert anti-atherosclerotic functionalities by decreasing hypercholesterolemia and inflammation in HFD-fed ApoE-/- mice.
DOI: 10.1039/c9fo02654a
PubMed: 31956875
Affiliations:
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R. China. lyzha@smu.edu.cn.</nlm:affiliation><country wicri:rule="url">République populaire de Chine</country></affiliation></author><author><name sortKey="Xiong, Fei" sort="Xiong, Fei" uniqKey="Xiong F" first="Fei" last="Xiong">Fei Xiong</name></author><author><name sortKey="Wu, Xinglong" sort="Wu, Xinglong" uniqKey="Wu X" first="Xinglong" last="Wu">Xinglong Wu</name></author><author><name sortKey="Chen, Junbin" sort="Chen, Junbin" uniqKey="Chen J" first="Junbin" last="Chen">Junbin Chen</name></author><author><name sortKey="Gu, Xiangfu" sort="Gu, Xiangfu" uniqKey="Gu X" first="Xiangfu" last="Gu">Xiangfu Gu</name></author><author><name sortKey="Su, Chuhong" sort="Su, Chuhong" uniqKey="Su C" first="Chuhong" last="Su">Chuhong Su</name></author><author><name sortKey="Xiao, Lingyu" sort="Xiao, Lingyu" uniqKey="Xiao L" first="Lingyu" last="Xiao">Lingyu Xiao</name></author><author><name sortKey="Zheng, Zhongdaixi" sort="Zheng, Zhongdaixi" uniqKey="Zheng Z" first="Zhongdaixi" last="Zheng">Zhongdaixi Zheng</name></author><author><name sortKey="Wei, Yuanhao" sort="Wei, Yuanhao" uniqKey="Wei Y" first="Yuanhao" last="Wei">Yuanhao Wei</name></author><author><name sortKey="Ullah, Hidayat" sort="Ullah, Hidayat" uniqKey="Ullah H" first="Hidayat" last="Ullah">Hidayat Ullah</name></author><author><name sortKey="Zha, Longying" sort="Zha, Longying" uniqKey="Zha L" first="Longying" last="Zha">Longying Zha</name></author></analytic><series><title level="j">Food & function</title><idno type="eISSN">2042-650X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Aorta (MeSH)</term><term>Atherosclerosis (drug therapy)</term><term>Diet, High-Fat (MeSH)</term><term>Hypercholesterolemia (drug therapy)</term><term>Inflammation (drug therapy)</term><term>Lipids (blood)</term><term>Male (MeSH)</term><term>Mice (MeSH)</term><term>Mice, Knockout, ApoE (MeSH)</term><term>NF-KappaB Inhibitor alpha (metabolism)</term><term>Phytochemicals (therapeutic use)</term><term>Plaque, Atherosclerotic (blood)</term><term>Saponins (pharmacology)</term><term>Signal Transduction (MeSH)</term><term>Soybeans (chemistry)</term><term>Toll-Like Receptor 4 (metabolism)</term><term>Transcription Factor RelA (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alimentation riche en graisse (MeSH)</term><term>Animaux (MeSH)</term><term>Aorte (MeSH)</term><term>Athérosclérose (traitement médicamenteux)</term><term>Composés phytochimiques (usage thérapeutique)</term><term>Facteur de transcription RelA (métabolisme)</term><term>Hypercholestérolémie (traitement médicamenteux)</term><term>Inflammation (traitement médicamenteux)</term><term>Inhibiteur alpha de NF-KappaB (métabolisme)</term><term>Lipides (sang)</term><term>Mâle (MeSH)</term><term>Plaque d'athérosclérose (sang)</term><term>Récepteur de type Toll-4 (métabolisme)</term><term>Saponines (pharmacologie)</term><term>Soja (composition chimique)</term><term>Souris (MeSH)</term><term>Souris invalidées pour les gènes ApoE (MeSH)</term><term>Transduction du signal (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Lipids</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Plaque, Atherosclerotic</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Soybeans</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Soja</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Atherosclerosis</term><term>Hypercholesterolemia</term><term>Inflammation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>NF-KappaB Inhibitor alpha</term><term>Toll-Like Receptor 4</term><term>Transcription Factor RelA</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de transcription RelA</term><term>Inhibiteur alpha de NF-KappaB</term><term>Récepteur de type Toll-4</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Saponines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Saponins</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Lipides</term><term>Plaque d'athérosclérose</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Phytochemicals</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Athérosclérose</term><term>Hypercholestérolémie</term><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Composés phytochimiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Aorta</term><term>Diet, High-Fat</term><term>Male</term><term>Mice</term><term>Mice, Knockout, ApoE</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alimentation riche en graisse</term><term>Animaux</term><term>Aorte</term><term>Mâle</term><term>Souris</term><term>Souris invalidées pour les gènes ApoE</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Atherosclerosis is a chronic inflammatory disease causing coronary heart attacks and strokes. Soyasaponins (SS), the phytochemicals naturally existing in soybeans and their products, have been shown to reduce hypercholesterolemia and inflammation, which are intimately related to the genesis and development of atherosclerosis. However, the anti-atherosclerotic functionality of soyasaponins remains unknown. The aim of this study was to investigate the effects of the supplementation of two types of soyasaponin monomers (A1 and A2) on atherosclerotic plaque formation, serum lipid profiles, and inflammation in ApoE gene knockout (ApoE-/-) mice. Sixty 5-week-old ApoE-/- male mice were fed with a high-fat diet (HFD) and intervened by SSA1 and SSA2 (10 and 20 μmol per kg BW, respectively) or simvastatin (10 μmol per kg BW) for 24 weeks. The atherosclerotic lesions in the aorta, aortic root, and innominate artery, lipid profile and inflammatory markers in serum, and TLR4/MyD88/NF-κB signaling in arterial tissues were determined. SSA1 and SSA2 decreased the plaque ratio in the aortic root and innominate artery but not in the entire aorta. In serum, SSA1 reduced TG, TC, and LDL-C but increased HDL-C; SSA2 decreased TC, TG, and LDL-C but did not affect HDL-C. Meanwhile, SSA1 increased TG, SSA2 increased TC, and both of them increased bile acids in the feces. SSA1 and SSA2 lowered TNF-α, MCP-1, and hs-crp in serum. Furthermore, SSA1 and SSA2 reduced the TLR4 and MyD88 expressions in the aorta and innominate artery and inhibited NF-κB p65 and IκBα phosphorylation in the aorta. These results suggest that SSA1 and SSA2 exert anti-atherosclerotic functionalities by decreasing hypercholesterolemia and inflammation in HFD-fed ApoE-/- mice.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31956875</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>07</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>07</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2042-650X</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Jan</Month><Day>29</Day></PubDate></JournalIssue><Title>Food & function</Title><ISOAbbreviation>Food Funct</ISOAbbreviation></Journal><ArticleTitle>Soyasaponins A<sub>1</sub> and A<sub>2</sub> exert anti-atherosclerotic functionalities by decreasing hypercholesterolemia and inflammation in high fat diet (HFD)-fed ApoE<sup>-/-</sup> mice.</ArticleTitle><Pagination><MedlinePgn>253-269</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1039/c9fo02654a</ELocationID><Abstract><AbstractText>Atherosclerosis is a chronic inflammatory disease causing coronary heart attacks and strokes. Soyasaponins (SS), the phytochemicals naturally existing in soybeans and their products, have been shown to reduce hypercholesterolemia and inflammation, which are intimately related to the genesis and development of atherosclerosis. However, the anti-atherosclerotic functionality of soyasaponins remains unknown. The aim of this study was to investigate the effects of the supplementation of two types of soyasaponin monomers (A1 and A2) on atherosclerotic plaque formation, serum lipid profiles, and inflammation in ApoE gene knockout (ApoE-/-) mice. Sixty 5-week-old ApoE-/- male mice were fed with a high-fat diet (HFD) and intervened by SSA1 and SSA2 (10 and 20 μmol per kg BW, respectively) or simvastatin (10 μmol per kg BW) for 24 weeks. The atherosclerotic lesions in the aorta, aortic root, and innominate artery, lipid profile and inflammatory markers in serum, and TLR4/MyD88/NF-κB signaling in arterial tissues were determined. SSA1 and SSA2 decreased the plaque ratio in the aortic root and innominate artery but not in the entire aorta. In serum, SSA1 reduced TG, TC, and LDL-C but increased HDL-C; SSA2 decreased TC, TG, and LDL-C but did not affect HDL-C. Meanwhile, SSA1 increased TG, SSA2 increased TC, and both of them increased bile acids in the feces. SSA1 and SSA2 lowered TNF-α, MCP-1, and hs-crp in serum. Furthermore, SSA1 and SSA2 reduced the TLR4 and MyD88 expressions in the aorta and innominate artery and inhibited NF-κB p65 and IκBα phosphorylation in the aorta. These results suggest that SSA1 and SSA2 exert anti-atherosclerotic functionalities by decreasing hypercholesterolemia and inflammation in HFD-fed ApoE-/- mice.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Qunying</ForeName><Initials>Q</Initials><Suffix></Suffix><AffiliationInfo><Affiliation>Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, P. R. China. lyzha@smu.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiong</LastName><ForeName>Fei</ForeName><Initials>F</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Xinglong</ForeName><Initials>X</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Junbin</ForeName><Initials>J</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Gu</LastName><ForeName>Xiangfu</ForeName><Initials>X</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>Chuhong</ForeName><Initials>C</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Xiao</LastName><ForeName>Lingyu</ForeName><Initials>L</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Zhongdaixi</ForeName><Initials>Z</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Yuanhao</ForeName><Initials>Y</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Ullah</LastName><ForeName>Hidayat</ForeName><Initials>H</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Zha</LastName><ForeName>Longying</ForeName><Initials>L</Initials><Suffix></Suffix></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Food Funct</MedlineTA><NlmUniqueID>101549033</NlmUniqueID><ISSNLinking>2042-6496</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008055">Lipids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064209">Phytochemicals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C498144">Rela protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012503">Saponins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C493487">Tlr4 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051197">Toll-Like Receptor 4</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051996">Transcription Factor RelA</NameOfSubstance></Chemical><Chemical><RegistryNumber>139874-52-5</RegistryNumber><NameOfSubstance UI="D000072000">NF-KappaB Inhibitor alpha</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001011" MajorTopicYN="N">Aorta</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050197" MajorTopicYN="N">Atherosclerosis</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059305" MajorTopicYN="N">Diet, High-Fat</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006937" MajorTopicYN="N">Hypercholesterolemia</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008055" MajorTopicYN="N">Lipids</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000074085" MajorTopicYN="N">Mice, Knockout, ApoE</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000072000" MajorTopicYN="N">NF-KappaB Inhibitor alpha</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D064209" MajorTopicYN="N">Phytochemicals</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058226" MajorTopicYN="N">Plaque, Atherosclerotic</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012503" MajorTopicYN="N">Saponins</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013025" MajorTopicYN="N">Soybeans</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051197" MajorTopicYN="N">Toll-Like Receptor 4</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051996" MajorTopicYN="N">Transcription Factor RelA</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>1</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>1</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31956875</ArticleId><ArticleId IdType="doi">10.1039/c9fo02654a</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chen, Junbin" sort="Chen, Junbin" uniqKey="Chen J" first="Junbin" last="Chen">Junbin Chen</name><name sortKey="Gu, Xiangfu" sort="Gu, Xiangfu" uniqKey="Gu X" first="Xiangfu" last="Gu">Xiangfu Gu</name><name sortKey="Su, Chuhong" sort="Su, Chuhong" uniqKey="Su C" first="Chuhong" last="Su">Chuhong Su</name><name sortKey="Ullah, Hidayat" sort="Ullah, Hidayat" uniqKey="Ullah H" first="Hidayat" last="Ullah">Hidayat Ullah</name><name sortKey="Wei, Yuanhao" sort="Wei, Yuanhao" uniqKey="Wei Y" first="Yuanhao" last="Wei">Yuanhao Wei</name><name sortKey="Wu, Xinglong" sort="Wu, Xinglong" uniqKey="Wu X" first="Xinglong" last="Wu">Xinglong Wu</name><name sortKey="Xiao, Lingyu" sort="Xiao, Lingyu" uniqKey="Xiao L" first="Lingyu" last="Xiao">Lingyu Xiao</name><name sortKey="Xiong, Fei" sort="Xiong, Fei" uniqKey="Xiong F" first="Fei" last="Xiong">Fei Xiong</name><name sortKey="Zha, Longying" sort="Zha, Longying" uniqKey="Zha L" first="Longying" last="Zha">Longying Zha</name><name sortKey="Zheng, Zhongdaixi" sort="Zheng, Zhongdaixi" uniqKey="Zheng Z" first="Zhongdaixi" last="Zheng">Zhongdaixi Zheng</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Xie, Qunying" sort="Xie, Qunying" uniqKey="Xie Q" first="Qunying" last="Xie">Qunying Xie</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PlantImRecepV1/Data/Main/Exploration
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Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000048 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= PlantImRecepV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:31956875
|texte= Soyasaponins A1 and A2 exert anti-atherosclerotic functionalities by decreasing hypercholesterolemia and inflammation in high fat diet (HFD)-fed ApoE-/- mice.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31956875" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PlantImRecepV1
| This area was generated with Dilib version V0.6.38. |  |